Interpreting antimicrobial resistance from bacterial whole-genome sequencing: prediction tools, database fragmentation, analytical trade-offs, and harmonized reporting
Whole-genome sequencing (WGS) has become a critical component of antimicrobial resistance (AMR) surveillance because it can characterize bacterial lineages, resistance determinants, and, when sequence resolution is sufficient, the mobile genetic elements that mediate dissemination. However, the practical value of WGS-b...