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Author

A. Abdelhameed

2 papers indexed here

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Open access Sep 2026

An Ultra‐Fast UPLC‐MS/MS Method for Quantifying Ivosidenib: Application to Assessment of Metabolic Stability in Human Liver Microsomes

Ivosidenib (Tibsovo) is a groundbreaking, first‐in‐class medication that specifically and reversibly blocks isocitrate dehydrogenase (IDH1), earning multiple FDA approvals for cancers harboring IDH1 mutations. This research developed a rapid, dependable, and sensitive UPLC‐MS/MS technique to assess the metabolic stabil...

M. Attwa, A. Abdelhameed, H. Alrabiah et al. · 0 citations
Aug 2026

Development of metal-free one-pot sequential synthesis of carbazolyl-thiazolidinones as anti-leukemic agents with potential β-catenin/c-MYC pathway modulation: from synthesis to in vitro and in silico profiling.

The developed metal-free synthesis provided a sustainable route to bioactive carbazolyl-thiazolidinones, and derivatives 4e, 4i, 4j, 4o could be promising leads for targeting Wnt/β-catenin/c-MYC signaling in leukemia.

S. Shehzadi, Sana Naveed, D. Khan et al. · 0 citations

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