Open access
Oct 2026
NHEJ-mediated DNA synapsis and RPA-driven MRX exonuclease balance DNA end resection to control DSB repair
DNA double-strand breaks (DSBs) are repaired by Ku-dependent non-homologous end-joining (NHEJ) or DNA end resection-dependent homologous recombination (HR). Previously, it was shown that short-range resection by MRX-pSae2 can remove Ku from DSBs and initiate resection, showing flexibility in DSB repair pathway choi...
Stefan Braunshier, E. Cannavó, Vincent Morin et al.
· Nature Communications · 0 citations