Mitotically driven cytoskeletal reorganization governs zebrafish left-right organizer detachment from EVL and lumen morphogenesis.
Left-right asymmetry in vertebrate embryos is established by the left-right organizer (LRO), with the zebrafish Kupffer's vesicle (KV) providing a tractable model for studying de novo epithelial morphogenesis. During KV formation, dorsal forerunner cells (DFCs) initially form polarized attachments to the enveloping lay...