Short-term efficacy and safety of intravenous ketamine for major depressive disorder in adolescents: a systematic review and metaanalysis of randomized and open-label studies
Background: Adolescent major depressive disorder (MDD) is associated with substantial impairment, suicide risk, and limited response to standard treatments. Intravenous ketamine has rapid antidepressant effects in adults, but pediatric evidence remains limited. This systematic review and meta-analysis evaluated the sho...