Author

A. Almehdi

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Review Open access Sep 2026

Purine nucleoside phosphorylase in breast cancer from metabolic regulation to targeted therapy: challenges and opportunities.

The rational design of selective inhibitors with improved pharmacokinetic profiles, combined with biomarker-driven patient stratification and combination therapy strategies, establishes a strong rationale for the development of clinically effective PNP-targeted therapies for breast cancer.

Sahar Salem, R. Hamdy, Sarra B. Shakartalla et al. · RSC Medicinal Chemistry · 0 citations

Aug 2026

Synthesis, Cytotoxicity, and Docking Studies of Novel Chalcones Incorporating 2‐(1 H ‐Indol‐1‐yl)‐ N ‐arylacetamide and Benzo[ d ]thiazole Moieties

Lead compound 7a significantly induced apoptosis and cell‐cycle arrest in MCF‐7 cells, as evidenced by increased apoptotic fraction, elevated sub‐G1 content, and accumulation of cells in the G2/M and S phases, and represents a promising multitarget anticancer lead for further optimization.

Noha Yehia Badr, A. Almehdi, Mohamed A. Ragheb et al. · ChemistrySelect · 0 citations