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Author

A. Almeida

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Review Open access Sep 2026

Descending Pain Modulation Across Pain States: Circuit Mechanisms, Neurochemical Plasticity, and Translational Perspectives

Descending pain modulation is a major determinant of pain processing across physiological and pathological conditions. Although descending pain modulation has long been recognized as bidirectional, capable of both inhibiting and facilitating nociceptive transmission, recent advances now allow it to be examined with far...

A. Almeida, I. Tavares · 0 citations
Review Open access Sep 2026

Pain Mechanisms in Fibromyalgia: An Integrative Narrative Review of Central, Peripheral, Neuroimmune, and Psychobiological Factors

Fibromyalgia is best understood as a heterogeneous nociplastic pain syndrome arising from partially overlapping central, peripheral, neuroimmune, autonomic, and psychobiological mechanisms whose relative contribution varies across patients.

Filipa Martins-Alves, A. Almeida · 0 citations

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