Matrix metalloproteinase-7 Induces Cellular Senescence By Activation Of p21 In Hyperglycemia
Background: Matrix metalloproteinase-7 (MMP7) belongs to a major enzyme group of proteinases involved in extracellular matrix degradation and in controlling several biological processes such as cell division, apoptosis, and the development of Diabetes mellitus (DM) and its complications. High glucose can elicit a damaging DNA response, which ultimately leads to p21-dependent senescence. This study aimed to detect the effects of elevated glucose on increased expression levels of MMP7 and p21 in human sample, and to identify the correlation between expression levels of MMP7 and p21. Materials and methods: The influence of high glucose on serum levels of MMP7 and p21 was evaluated in 90 subjects, divided into two groups (diabetic patients, and healthy control). The key indicators of the male and female participants, in each group, were evaluated based on fasting blood sugar (FBS) and glycosylated hemoglobin (HbA1c). Finally the correlation among all study variables was established. Results: Expression levels of MMP7 and p21 were significantly higher in participants with diabetes and HbA1c, as compared to the healthy controls. A positive correlation was established between MMP7 and p21 within the study group. Conclusions: The elevated blood glucose enhanced the expression of MMP7 and p21 in diabetic patients, highlighting potential influence on disease progression. The positive correlation between MMP7 and p21 offers new insight into the role of MMP7 in promoting cellular apoptosis in diabetes.