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Sep 2026

Structure-Based Virtual Screening and Computational Evaluation of Putative Mushroom-Associated Natural Compounds as Janus Kinase 1 (JAK1) Inhibitors: An In Silico Study.

INTRODUCTION/OBJECTIVE Janus kinase 1 (JAK1) is a key controller and regulator of cytokinemediated immune responses and an effective therapeutic target in autoimmune and inflammatory diseases. In the present study, an in silico workflow was implemented to identify secondary metabolites of mushrooms as prospective JAK1-...

Bushra Shakoor, Ali Irfan, M. T. Muhammed et al. · 0 citations
Review Open access Aug 2026

Effect of Metformin on Progression from Prediabetes to Type 2 Diabetes Mellitus: A Systematic Review and Meta-Analysis

Background/Objectives: Prediabetes is a highly prevalent metabolic condition associated with an increased risk of progression to type 2 diabetes mellitus (T2DM) and related cardiometabolic complications. Although lifestyle modification remains the cornerstone of diabetes prevention, long-term adherence is often challen...

Lara Osama Al Hartany, Marya Aref Alghorab, Maya Faissal Alhomieed et al. · 0 citations

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