322. Dysregulation of Cav3.1 and Cav1.2 in vulnerable DLPFC pyramidal neurons: a mechanistic link to cognitive disorders
Abstract Background The recently evolved dorsolateral prefrontal cortex (DLPFC) is essential to higher cognition, working memory and abstract thought, with pyramidal cell microcircuits in layer III that are able to excite each other to keep information “in mind” without sensory stimulation1,2. However, these pyramidal...