Author

Amir Asiaee

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Open access Sep 2026

Immune checkpoint blockade reshapes drug-associated toxicity: a pharmacovigilance atlas of drug-ICI interactions

Importance: Immune checkpoint inhibitors (ICIs) produce diverse immune toxicities, but whether checkpoint blockade also modifies associations between other drugs and adverse events is poorly understood. Objective: To define ICI-associated toxicity organization and determine whether drug-associated adverse events and on...

E. Mukherjee, A. Asiaee, D. Park et al. · medRxiv · 0 citations

Review Open access Aug 2026

Keystone Epitope Theory: Implications for Hypersensitivity, Autoimmunity, and Transplantation

The phylogenetic basis for this proposal is that herpesviruses and their vertebrate hosts have co-adapted over hundreds of millions of years, and that this co-evolutionary relationship is replayed ontogenetically as each individual acquires these infections and builds tissue-specific immune memory.

Simon Mallal, Amir Asiaee, Elizabeth J. Phillips · Pathogens and Immunity · 2 citations

Review Aug 2026

Keystone Epitope Theory: An Ecological Perspective on RNA Viruses, Tumor Immunoediting, and Vaccine Design

3 vaccine design principles are concluded: prioritize epitopes where substitutions carry measurable fitness costs, avoid immunogens dominated by mutable targets, and account for antigen presentation context and inhibitory NK signaling when evaluating epitope choice.

Simon Mallal, Amir Asiaee · Pathogens and Immunity · 3 citations