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Author

A. Awad

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2 papers indexed here

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Sep 2026

Cardioprotective role of vincamine in cyclophosphamide-induced cardiotoxicity through modulation of AMPK/SIRT1, PI3K/Akt, and MAPK pathways.

VIN attenuated changes in the AMPK/SIRT1 and PI3K/Akt axes, MAPK, TLR4/NF-κB p65 signaling, as well as NLRP3-related signaling in a dose-responsive manner, and its cardioprotective effects were accompanied by improved redox balance, increased AMPK/SIRT1 and PI3K/Akt expression, reduced phosphorylated MAPK abundance, an...

Mohammed Tarek Seddek, A. Awad, Marwa E. Elsherbiny et al. · 0 citations
Jul 2026

Synergistic cardioprotection by liraglutide and deferoxamine against doxorubicin-induced cardiotoxicity via modulation of ACSL-4/Nrf-2/GPX-4 signaling.

It is demonstrated that simultaneous targeting of iron overload and antioxidant signaling confers enhanced cardioprotection against Dox-induced injury and the Lira-DFO combination may represent a promising adjunct strategy to mitigate anthracycline-associated cardiotoxicity.

Nada Monir, O. Galal, A. Awad et al. · 0 citations

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