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A. B. Federici

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Review Open access Oct 2026

Von Willebrand Disease (VWD) 100 years after its first description: the research of Italian investigators for a better management of VWD patients

Since the first description of the von Willebrand disease (VWD) families by Erik von Willebrand in 1926, VWD has been considered an inherited bleeding disorder completely different from hemophilia, already known for many years. The pivotal role of the adhesive glycoprotein von Willebrand factor in the early phases of h...

A. B. Federici, G. Castaman, Paolo Gresele et al. · Bleeding Thrombosis and Vasc... · 0 citations

Open access Oct 2026

CO-64 | REAPPRAISAL OF DESMOPRESSIN FOR MANAGEMENT OF MILD/MODERATE VON WILLEBRAND DISEASE: RESULTS OF A RETROSPECTIVE ANALYSIS IN 127 ITALIAN PATIENTS SUGGEST FURTHER ORGANIZATION OF PROSPECTIVE OBSERVATIONAL STUDIES TO PREDICT DESMOPRESSIN FAILURE WITH IMMEDIATE VWF CONCENTRATES REQUIREMENT

Background. Desmopressin (DDAVP) has always been considered the treatment of choice for patients with mild/moderate von Willebrand disease (VWD), but no standardized criteria have been reported so far to predict the benefits/limits of DDAVP in the management of a very large cohort of VWD.Aims. To establish correct indi...

A. B. Federici · Bleeding Thrombosis and Vasc... · 0 citations