Author

A. Bateman

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Open access Jul 2026

Structural basis of biofilm formation mediated by the Pseudomonas aeruginosa fibrillar adhesin CdrA

An electron cryomicroscopy structure of the 60 kDa CdrA adhesive N-terminus is reported, which combined with electron cryotomography of focused-ion beam milled specimens, allows for a complete in situ model of the native adhesin and reveals a small adhesive domain (called ADEPT) at the distal tip of CdrA that is nearly perfectly conserved across the P. aeruginosa pangenome.

Olivia E. R. Smith, Camila M. Clemente, Antonina Andreeva et al. · bioRxiv · 0 citations

Open access Aug 2026

Large-scale structure prediction of DUF-containing protein-protein interactions

Whether AlphaFold 3 complex prediction, combined with STRING evidence and domain-level analysis of interfaces and interaction partners, can help identify and characterize DUF-containing proteins and suggest roles for DUF4130 in nucleic-acid-associated radical-SAM biology and DUF5819 in a bacterial system related to vitamin-K-dependent carboxylation are suggested.

Lino Riepenhausen, Francesco Costa, Antonina Andreeva et al. · bioRxiv · 0 citations