Author

A. Bauschen

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Open access Sep 2026

Spatial transcriptomics reveal impaired metabolic liver zonation in acute-on-chronic liver failure.

BACKGROUND AND AIMS Extrahepatic organ failures are key determinants of acute-on-chronic liver failure (ACLF). While the role of systemic inflammation and mitochondrial dysfunction in the pathogenesis of ACLF is well known, the contribution of the liver itself is less understood. We therefore performed transcriptome an...

Mona-May Langer, H. Stadler, M. Mannewitz et al. · JHEP Reports · 0 citations

Open access Sep 2026

Vitamin D Receptor Polymorphisms Are Associated with 25(OH)D3 Concentrations and Systemic Inflammation in Decompensated Cirrhosis

Background/Objectives: Vitamin D regulates both the adaptive and the innate immune system, while having anti-inflammatory, immunomodulatory and anti-fibrotic properties. In clinical studies, 25(OH)D3 deficiency was associated with systemic inflammation, but it is unclear whether these associations are causal. In this s...

A. Bauschen, Mona-May Langer, H. Stadler et al. · Nutrients · 0 citations