Author

A. Binsaleh

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Oct 2026

Computationally Guided Design and Biological Evaluation of New Benzoxazole Bridged thiazole based 1,3-Oxazole Conjugates as Potential Anti-Alzheimer's Agents: Molecular Docking, DFT and sADMET Studies

Alzheimer's disease (AD) remains one of the most devastating neurodegenerative disorders, characterized by progressive cognitive impairment associated with cholinergic dysfunction. In pursuit of potent dual cholinesterase inhibitors, a series of structurally diverse benzoxazole linked thiazole based 1,3-oxazole molec...

Syeda Farwa Naqvi, Hina Sarfraz, Abdul Rehman et al. · Journal of Computational Bio... · 0 citations

Open access Oct 2026

Integrated Transcriptomic and Network Analysis Identifies Diagnostic and Immune-Associated Hub Genes in Urothelial Carcinoma

Background: Urothelial carcinoma exhibits molecular heterogeneity, high recurrence, and progression rates, and is poorly diagnosed and treated. Transcriptomic and systems-biology analyses can detect dysregulated genes, signaling pathways, and interactions of immune cells. Proposed biomarkers, however, have not been val...

Shaza N. Alkhatib, A. Binsaleh, N. Al-Hoshani et al. · Biomedicines · 0 citations

Oct 2026

Integrating in vitro and in silico correlation of thiazole-based carboxamide derivatives as promising SARS-CoV-2 papain-like protease inhibitors: a versatile approach for COVID-19 therapy

Abstract A new series of thiazole-based carboxamide derivatives (5–12) was designed, synthesized with structural elucidation performed using standard spectroscopic techniques including NMR and HRMS. The synthesized compounds were evaluated for their inhibitory activity against SARS-CoV-2 papain-like protease (PLpro) an...

Imran Khan, Rafaqat Hussain, Hina Sarfraz et al. · Zeitschrift für Naturforschu... · 0 citations

Sep 2026

Real-world pharmacogenomics-guided antihypertensive treatment response in clinical practice underrepresented population: implications for precision prescribing and medication safety

This retrospective cohort study analyzed 1,247 hypertensive patients treated at Kuwait Teaching Hospital (KTH), Peshawar, between January 2023 and August 2025 to evaluate associations between pharmacogenomics variants and antihypertensive therapy response using electronic health record (EHR) data from Khyber Pakhtunkhw...

Nawal Alsubaie, Muhammad Ilyas, Z. A. Shah et al. · European Journal of Clinical... · 0 citations

Aug 2026

Thymol dietary supplementation mitigates microplastic-induced hematological disturbances, oxidative stress, immunosuppression, gene dysregulation, and histopathological alterations in Nile tilapia.

Thymol supplementation against polystyrene microplastics exposure in Nile tilapia may be considered a helpful nutritional additive for lessening the negative impacts of PS-MPs.

Badriyah S. Alotaibi, Amany Abdel-Rahman Mohamed, Tarek Khamis et al. · Research in Veterinary Scien... · 0 citations