Jul 2026
Transgene Sequence Codon Optimization and Composition Determines Replication Competence of Self-Amplifying RNA.
An underappreciated constraint in saRNA therapeutics is defined and saRNA-specific payload design frameworks that incorporate alphavirus associated compositional biases during transgene sequence optimization are motivated.
N. V. Bathula, Shekinah K V Soriano, Cynthia Huang et al.
· Molecular Therapy · 1 citation