Optimization and Miniaturization of a Human Intestinal Organoid Neutralization Assay for Evaluating Human Norovirus Antibody Responses.
Human noroviruses (HuNoVs) are the principal etiological agents of acute viral gastroenteritis worldwide. While conventional 96-well human intestinal organoid (HIO) neutralization assays provide a physiologically relevant assessment of neutralizing antibody (nAb) responses, sample volume requirements (50µL for 96 wells...