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Sponsored Artificial Intelligence: A Modern Approach, Global Edition Artificial Intelligence: A Modern Approach, Global Edition

Author

A. Bougea

h-index 29 View on Semantic Scholar

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Review Open access Aug 2026

Genetic Architecture of Synaptic Failure in Dementia with Lewy Bodies: From α-Synuclein Proteoforms to GBA1-Mediated Plasticity Deficits

It is argued that GBA1 loss-of-function and the resulting accumulation of glucosylceramide stabilise specific neurotoxic α-synuclein proteoforms, including soluble oligomers and self-templating conformational strains bearing defined post-translational modifications, and identifies the synapse as the most tractable node...

A. Bougea · 0 citations
Review 2026

Microglial advances in Parkinson's disease.

Advanced fluid biomarkers, such as seed amplification assays (SAA), alongside multidimensional neuroimaging techniques (PET, SPECT, MRI), are proving crucial for detecting these early microglial and pathological changes to guide personalized, disease-modifying therapies of PD.

Manuel Debasa-Mouce, Alberto Ouro, J. De Leon et al. · 0 citations

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