Author

A. Brink-Kjaer

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Open access Aug 2026

Physiological Signatures Derived from Wrist Accelerometry Improve Detection of Isolated REM Sleep Behavior Disorder

Isolated REM sleep behavior disorder (iRBD) is the strongest prodromal marker of -synucleinopathies, but polysomnography is impractical for population-scale screening and questionnaires lack sufficient specificity. Beyond nocturnal movement, recently published models can derive sleep staging and other physiological sig...

A. Brink-Kjaer, Johanne Niman Abildgaard, N. Lorenzen et al. · medRxiv · 0 citations

#artificial intelligence Preprint Sep 2026

Learning transferable human physiology from two million hours of sleep with SleepFM-2

Sleep provides a nightly window into health by capturing coordinated activity across the brain, heart, muscles and respiratory system. We introduce SleepFM-2, a sleep foundation model developed and evaluated on 282,511 polysomnography recordings from 26 cohorts, including 235,865 used for pretraining. These data span m...

R. Thapa, Christopher Sun, W. Lehn-Schiøler et al. · 0 citations