A. Cagol

Macro- and microstructural changes in the upper cervical spinal cord and their clinical correlates in multiple sclerosis

Spinal cord (SC) damage is central to multiple sclerosis (MS) progression but remains difficult to quantify with conventional magnetic resonance imaging (MRI). To characterize upper cervical SC pathology using quantitative MRI (qMRI) and assess longitudinal changes and predictors of clinical progression and...

NeuroImage: Clinical

Central vein sign and paramagnetic rim lesions in pediatric-onset multiple sclerosis: a systematic review and meta-analysis

Susceptibility-based MRI biomarkers, including paramagnetic rim lesions (PRLs) and central vein sign (CVS), were incorporated into the 2024 McDonald criteria because they improve diagnostic specificity in adult-onset MS; however, their role in pediatric-onset MS (POMS) remains incompletely defined. To synthesize curren...

Serum Glial Fibrillary Acidic Protein Dynamics, Disease Progression, and Therapy Response in Multiple Sclerosis.

It is suggested that serum GFAP may serve as a biomarker for personalized risk stratification and treatment monitoring and as a screening tool to reduce cohort size in clinical trials targeting MS progression.

Choroid plexus morphological and microstructural changes across inflammatory phenotypes in multiple sclerosis.

CP volume was increased in both active RMS and inactive PMS and was associated with lower total and cortical brain volumes, suggesting CP volume may reflect processes beyond MS-specific pathology, including physiological factors.