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Author

A. Callebaut

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Review Open access Sep 2026

Autoantibodies and T Cells Target Citrullinated and Homocitrullinated Antigens in Rheumatoid Arthritis

Rheumatoid Arthritis (RA) is a prevalent form of inflammatory arthritis in which post‐translational modifications are known to play a major role in the loss of tolerance. This review summarizes current knowledge of the role that such modifications play in the disease. Most individuals with RA have antibody responses di...

Eddie A. James, A. Callebaut, J. Buckner et al. · 0 citations
Review Open access Aug 2026

Citrullination and Deamidation in Type 1 Diabetes: Linking Beta Cell Stress to Neoantigen‐Driven Autoimmunity

Citrullination and deamidation are post‐translational modifications (PTMs) increasingly recognized as important contributors to neoepitope formation in type 1 diabetes (T1D). Under inflammatory and endoplasmic reticulum stress conditions, beta cells activate calcium‐dependent peptidylarginine deiminase and transglutami...

A. Callebaut, Ylke Bruggeman, C. Mathieu et al. · 0 citations

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