Open access
Sep 2026
TM184C is a GPCR-like regulator of intercellular exchange and autophagy
Sequence similarity underlies most protein annotation, yet many functions remain hidden beyond detectable homology1, 2–3. By mining millions of AlphaFold2 models4,5, we identify two human families of ‘superdark’ seven-transmembrane proteins—TM184 and PRRT—with structural homology to G-protein-coupled receptors (GPCRs)....
Kyutae D. Lee, Sam Taylor, Jennifer Arcuri et al.
· Nature · 1 citation