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Author

A. Carvalho

2 papers indexed here

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Review Open access Sep 2026

Immunotherapy for invasive Candida infections: Translating host-directed strategies into clinical practice.

BACKGROUND Candida infections are a leading cause of invasive fungal disease (IFD), especially among critically ill and immunocompromised patients. Despite available pathogen-directed antifungal therapies, outcomes remain unsatisfactory with high associated morbidity and mortality rates. Increasing recognition of immun...

R. Sprute, Shakti Singh, Heather R. Conti et al. · 0 citations
Open access Sep 2026

Outbreaks of fluconazole-resistant Candida parapsilosis are driven by low-biofilm-producing isolates that emerge under host selection

It is shown that FLCR-Cp isolates responsible for prolonged, multi-country outbreaks consistently exhibit a striking low-biofilm-producing (LBP) phenotype, overturning the assumption that robust biofilm formation drives outbreak persistence and identifying biofilm attenuation as an adaptive tradeoff that promotes immun...

F. Daneshnia, Deepika Gunasekaran, S. Bergin et al. · 2 citations · ⚡1

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