Jul 2026
Sp1 links CD46 to CD4 T cell metabolic fitness, survival, and retroviral control.
It is shown that the CD46 signaling domain cytoplasmic tail 1 (CYT-1) engages the transcription factor Sp1 in human CD4 T cells to dynamically modulate Sp1-DNA interactions, defining a human-specific transcriptional mechanism linking complement signaling to metabolic adaptation, apoptosis regulation, and antiviral defe...
Parul Singh, Luopin Wang, Pavitra Ramdas et al.
· Science immunology · 0 citations