Background Metastatic breast cancer (MBC) in older patients has distinct clinical and histologic characteristics. Elucidating the genomic basis of MBC helps identify potential therapeutic targets to improve outcomes for older patients with MBC. Patients and methods Using a prospective database and targeted DNA sequenci...
H. Gupta, K. Brantley, T. Grinda et al.· ESMO Open· 0 citations
A large-scale international programme—the Human Cancer Models Initiative—is presented, which involved the generation of a resource of 665 next-generation models from 2,780 donors with 25 cancer types and integrated tumour–model whole genome, exome, methylome and transcriptome analyses.
Dina Elharouni, Mushriq Al-Jazrawe, Seongmin Choi et al.· Nature· 7 citations
Results show that protein fitness estimates can facilitate the identification of resistance mutations by filtering mutations with a low estimated fitness, indicating that protein language model-based protein fitness estimates could be a computationally efficient method to filter mutations without having to model the ne...
Dominik Schwarz, Sven H. Giese, Akansha Gupta et al.· Journal of Chemical Informat...· 0 citations
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