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A. Cherniack

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Open access Sep 2026

Tumor genomic landscape of older patients with metastatic breast cancer☆

Background Metastatic breast cancer (MBC) in older patients has distinct clinical and histologic characteristics. Elucidating the genomic basis of MBC helps identify potential therapeutic targets to improve outcomes for older patients with MBC. Patients and methods Using a prospective database and targeted DNA sequenci...

H. Gupta, K. Brantley, T. Grinda et al. · 0 citations
Open access Aug 2026

A compendium of next-generation patient-derived models for diverse cancers

A large-scale international programme—the Human Cancer Models Initiative—is presented, which involved the generation of a resource of 665 next-generation models from 2,780 donors with 25 cancer types and integrated tumour–model whole genome, exome, methylome and transcriptome analyses.

Dina Elharouni, Mushriq Al-Jazrawe, Seongmin Choi et al. · 7 citations
Jul 2026

Protein Language Model-Based Fitness Estimates Facilitate Resistance Mutation Identification

Results show that protein fitness estimates can facilitate the identification of resistance mutations by filtering mutations with a low estimated fitness, indicating that protein language model-based protein fitness estimates could be a computationally efficient method to filter mutations without having to model the ne...

Dominik Schwarz, Sven H. Giese, Akansha Gupta et al. · 0 citations

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