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Open access Sep 2026

Lithium and quetiapine augmentation therapy in treatment-resistant depression with atypical features.

Up to 50% of patients with depression do not adequately respond to standard antidepressant therapy, resulting in treatment-resistant depression (TRD), for which lithium and quetiapine are common augmentation strategies. Atypical depression, characterised by mood reactivity and reversed neurovegetative symptoms, is a cl...

G. Ingrosso, S. Masier, A. D'Agostino et al. · 0 citations
Review Open access Sep 2026

Atypical depression: state of the art and future perspectives

Atypical depression was first described in the 1950s, but after a surge of interest and publications in the 1980s, this construct appears to have fallen out of focus, with comparatively less literature produced over recent decades. Despite different conceptualisations proposed by different authors, atypical depression...

G. Ingrosso, A. Cleare · 0 citations
Open access Sep 2026

588. Lithium and Quetiapine Augmentation Therapy in treatment-resistant depression with atypical features

Abstract Background Treatment-resistant depression (TRD) affects up to half of patients with major depressive disorder and is associated with poorer health outcomes. Lithium and quetiapine are established augmentation strategies in cases of TRD, but there is limited evidence to inform treatment choice in different depr...

G. Ingrosso, S. Masier, A. D'Agostino et al. · 0 citations

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