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Author

A. Croft

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Open access Sep 2026

CD248/Endosialin regulates synovial fibroblast state to control coupling of inflammation and bone damage in murine models of immune-mediated inflammatory arthritis and ageing.

The data suggests that the high levels of CD248 expression seen on synovial fibroblasts provides a protective brake that attenuates bone damage by preventing the polarisation of emergent fibroblasts towards a destructive phenotype.

Samuel Kemble, C. Wehmeyer, James M. Brown et al. · 0 citations
Open access Aug 2026

Synovial lining macrophages form during early postnatal life via fetal-derived CX3CR1+ cells and AQP1+ intermediates.

It is found that the lining is immature in fetal human and newborn mouse joints, and early postnatal life is a critical window for synovial lining maturation with implications for joint health and disease.

Marlene S. Magalhaes, B. Malengier-Devlies, Guillaume Seuzaret et al. · 0 citations

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