Author

A. D. de Freitas

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Open access Sep 2026

Heterologous Antigen Regimen and Bicistronic DNA Vaccination Targeting HPV16 E5 and E7 Oncoproteins: Immunoinformatics and Preclinical Antitumor Efficacy

Persistent infection with high-risk human papillomavirus, particularly HPV16, is a major cause of cervical cancer and orogenital malignancies. Therapeutic DNA vaccines targeting viral oncoproteins represent a promising strategy to induce antitumor immune responses. However, the impact of antigen combinations in bicistr...

Ingrid Andrêssa de Moura, Karina Mayumi Tani Bezerra de Melo, L. R. S. Leal et al. · Molecules · 0 citations

Review Open access Sep 2026

HPV-associated breast cancer: Insights into molecular and epigenetic alterations.

Breast cancer is a major public health concern and the leading cause of cancer-related death among women. The controversial role of Human Papillomavirus (HPV) infection in breast cancer remains not fully elucidated, but accumulating evidence points toward the confirmation of genetic and epigenetic alterations induced b...

Vanessa Emanuelle Pereira Santos, Ingrid Andrêssa de Moura, Beatriz Eda de Oliveira Isídio et al. · Cellular Signalling · 0 citations

Open access Aug 2026

Transcriptional modulation of the PI3K/AKT/mTOR signaling pathway mediated by HPV16 E5, E6, and E7 oncogene expression in breast cancer

The high expression of E5—associated with immune evasion—combined with reduced mTOR expression suggests that HPV16 status may influence therapeutic response in breast cancer patients, reinforcing the importance of further studies investigating HPV activity in breast tumors to better understand its biological and clinic...

Beatriz Eda de Oliveira Isídio, Pedro Henrique Bezerra Fontes, Gabriel Rômulo Parente da Silva et al. · Exploration of Targeted Anti... · 1 citation