Open access
Oct 2026
Network‐dependent remote effects and local tau burden jointly shape neuronal dysfunction in Alzheimer's disease
Abstract BACKGROUND Tau pathology in Alzheimer's disease (AD) propagates along the brain's connectome, yet the mechanisms by which tau drives neuronal dysfunction remain unclear. We hypothesized that dysfunction primarily emerges in regions close to tau‐harboring epicenters. METHODS One hundred thirty‐one amyloid‐posit...
Lukas Frontzkowski, Sebastian N. Roemer-Cassiano, Johannes S. Gnörich et al.
· Alzheimer's & Dementia · 0 citations