Open access
Aug 2026
Remodeling oligodendrocyte lipid metabolism via liver X receptors overcomes inflammatory blockade of remyelination
Multiple sclerosis is characterized by immune-mediated demyelination and inefficient remyelination, owing to impaired differentiation of oligodendrocyte precursor cells (OPCs) into myelinating oligodendrocytes (OLs). Inflammatory cytokines within multiple sclerosis lesions inhibit OPC maturation and induce an immune-li...
Judy J Lee, Matthew D. Smith, Xiaojing Deng et al.
· bioRxiv · 0 citations