Author

A. DiMarco

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Jul 2026

Discovery and Preclinical Characterization of I-0436650, a Selective SHP2 Allosteric Inhibitor for RAS-Driven Cancers.

I-0436650 is a low nanomolar allosteric inhibitor of human wild-type SHP2 and strongly inhibits ERK phosphorylation in cells, demonstrating the potential of vertical inhibition strategies.

Alina Ciammaichella, Francesca Puca, Danilo Fabbrini et al. · Journal of Medicinal Chemist... · 0 citations