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Sponsored Artificial Intelligence: A Modern Approach, Global Edition Artificial Intelligence: A Modern Approach, Global Edition

Author

A. Dimitriou

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2 papers indexed here

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Open access Sep 2026

MyD88 deficiency modestly attenuates disease in a Leigh syndrome mouse model while enrofloxacin accelerates disease.

Primary genetic mitochondrial diseases (GMDs) are clinically and genetically diverse diseases. Leigh syndrome (LS), the most common pediatric presentation of GMD is a severe progressive multi-system disorder with diverse manifestations. No effective treatments currently exist. Recent data from the Ndufs4(-/-) LS mouse...

Allison R. Hanaford, Elizaveta A. Olkhova, Ryan W. Liao et al. · 0 citations
Open access Aug 2026

Immune profiling and treatment cessation provide mechanistic insights into disease pathogenesis and considerations for translating pre-clinical strategies in Leigh syndrome

Hypoxia-cessation is established as a novel method for synchronizing inflammatory disease onset in the Ndufs4(-/-) model which will be useful in future mechanistic studies and have major implications for the therapeutic translation of both hypoxia and immune targeting interventions.

Elizaveta A. Olkhova, E. Kayser, A. Dimitriou et al. · 0 citations

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