Author

A. Dinkova-Kostova

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Review Open access Oct 2026

Cysteine-based molecular switches: a focus on KEAP1 and BACH1 in regulating the antioxidant response.

Due to the chemical properties of their thiol groups and the surrounding amino acid environment, specific cysteines in proteins serve as the principal intracellular sensors for oxidants and electrophiles. In this review, we focus on the ubiquitin ligase substrate adaptor Kelch-like ECH-associated protein 1 (KEAP1) and...

Jia-Lin Feng, A. Dinkova-Kostova · Archives of Toxicology · 0 citations

Open access Sep 2026

Genetic and pharmacologic inhibition of Keap1 dampens the pro-fibrotic program in human hepatic stellate cells

The increasing prevalence of chronic liver diseases (CLDs) is a global health concern. CLDs can cause fibrosis, and there is an urgent need for antifibrotic agents. The primary driver of fibrogenesis, transforming growth factor beta 1 (TGF-β1), activates hepatic stellate cells (HSCs), which are responsible for hepato...

Sharadha Dayalan Naidu, R. Madsen, Boushra Bathish et al. · Scientific Reports · 0 citations