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Author

A. Dowle

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2 papers indexed here

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Open access Aug 2026

Structural basis for covalent inhibition of sulfatases by sulfamate warheads

The enzymatic removal of sulfate groups regulates processes ranging from steroid metabolism to carbohydrate degradation. Most sulfatases belong to the S1 family, whose members use a co-translationally installed formylglycine residue to hydrolyse sulfate esters. Arylsulfamates are potent covalent inhibitors of aryl and...

C. Tomlinson, Stefano Elli, Morgan Batiste-Simms et al. · 0 citations
Open access Sep 2026

A pH-dependent protein kinase cascade regulates divergent differentiation of Leishmania in the sand fly

Leishmania parasites must rapidly adapt to fluctuating environments to ensure survival and transmission. While acidic pH in the sand fly vector is a conserved developmental trigger, sensing mechanisms remain poorly understood. Using a barcoded protein kinase library, we screened for regulators of acid adaptation in Lei...

L. V. de Liz, J. Sádlová, Barbora Bečvářová et al. · 0 citations

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