Author

A. Durbin

3 papers indexed here

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Sep 2026

Abstract PR002: A Genome-Derived Non-Coding Cell State Reporter Guides Therapeutic Strategies for Transcriptional Reprogramming in Neuroblastoma

Sequential changes in transcriptional cell state are essential for normal development and are coopted in cancer. Controlling these changes for therapeutic benefit has been challenged by a lack of tools reflecting distinct states in live cells. Here, using the pediatric solid tumor high-risk neuroblastoma, which displ...

Noha A. M. Shendy, Yang E. Zhang, Brian J. Abraham et al. · Cancer Research · 0 citations

Sep 2026

Abstract A022: Cell state-directed integrated functional genomics reveals TAB1 as a central controller of the neuroblastoma chemoresistant mesenchymal cell state

Resistance to conventional chemotherapies is a major cause of cancer patient relapse and subsequent death. The fundamental biological properties of tumor cells are not only driven by acquired genetic mutations, but also by aberrant epigenetic regulation leading to corresponding changes in the expressed transcriptome....

G. McKay-Corkum, Noha A. M. Shendy, S. Nance et al. · Cancer Research · 0 citations

Sep 2026

Abstract B011: Oncogenic neomorphic ATRX-in-frame fusion mutations mechanistically enforce a new immunotherapeutic vulnerability through altered epigenomic regulation

Children with high-risk neuroblastomas (NB) marked by in-frame fusion mutations in the ATRX chromatin remodeler (“ATRX-IFF”) display highly chemoresistant disease. As a result, despite multi-modality therapies, these children have poor overall survival. At present, there are no molecularly-targeted agents for these t...

M. A. Mohammad Nezhady, S. Sati, D. E. Prado et al. · Cancer Research · 0 citations