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A. E. Cicek

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Open access Aug 2026

REFCON: Reference-free and robust copy number inference in single-cell tumor transcriptomes

REFCON is introduced, a deep-learning model that enables reference-free copy number profiling from scRNA-seq data collected without matched normals, and profiles pure tumors, generalizes to unseen tissues and platforms, and stays robust to cohort composition.

M. Gençtürk, A. E. Cicek · bioRxiv · 0 citations