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A. E. Stepanova

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Open access Sep 2026

Trigonelline improves mitochondrial calcium homeostasis and reduces calpain activity after skeletal muscle ischemia-reperfusion injury in mice.

Skeletal muscle ischemia-reperfusion injury (IRI) causes persistent tissue damage and functional impairment, partly through mitochondrial calcium dysregulation and calpain-mediated proteolysis. This study investigated whether trigonelline (TG), a natural alkaloid, improves skeletal muscle recovery and mitochondrial hom...

A. E. Stepanova, A. S. Ustinova, A. D. Igoshkina et al. · 0 citations

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