Author

A. Ebert

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Open access Sep 2026

Nx3 Is a Z-Disk Structural and Signaling Hub That Is Reduced in Heart Failure.

BACKGROUND Nx3 (novex-3) is an exceptionally small isoform of the giant protein titin, whose structural and functional roles within the sarcomere remain poorly understood. METHODS AND RESULTS We used a comprehensive, multimodal approach to define the key properties of Nx3 in healthy and failing hearts, including its...

W. Linke, Lisa Kümper, A. Fomin et al. · Circulation Research · 0 citations

Open access Jul 2026

SGLT2 inhibition improves sarcomere contractile dysfunction in human models of dilated cardiomyopathy

Sodium–glucose cotransporter 2 inhibitors (SGLT2i) are now widely applied in treatment plans for heart failure with reduced ejection fraction (HFrEF) patients, regardless of the presence of diabetes. SGLT2i, such as empagliflozin (EMP), reduce the risk of cardiovascular death and heart failure hospitalizations in HFrEF...

Daria Plota, H. N. Saleem, K. Lin et al. · Journal of Translational Med... · 0 citations