A. Egli

A standardized collection of human stool and fermented food microbiomes from the Launch Phase of the Microbiota Vault Initiative

The human gut microbiome and traditional food systems are threatened by lifestyle changes linked with industrialization. The gut microbiome plays a key role in human health, yet publicly available microbiome data lack global representation. Similarly, while fermented foods serve as an important nutritional and cultur...

Evaluation of six generative large language models answering pre-analytical questions in medical microbiology.

OBJECTIVES Large language models (LLMs) have the potential to be integrated into diagnostics workflows, yet their reliability in pre-analytical diagnostic stewardship remains uncertain. We aimed to evaluate the performance of six LLMs answering common pre-analytical questions in the domain of medical microbiology. Next...

Emerging Corynebacterium diphtheriae ST-212 cluster with truncated tox gene linked by possible sexual transmission.

Machine learning-guided discovery of a conserved plasmid proteomic signature enables MALDI-TOF MS detection of pOXA-48-carrying Enterobacterales

This approach reframes the resistance prediction task from inferring a resistance phenotype to detecting a conserved plasmid through its expressed proteomic signature and has the potential to enable rapid MALDI-TOF MS-based diagnostics for a wide range of plasmid-based resistance determinants.