Obesity is a systemic driver of cellular dysfunction that reshapes tissue biology well beyond energy storage, extending its influence to the regenerative machinery of the body. Mesenchymal stem/stromal cells (MSCs) support tissue repair through immunomodulatory, angiogenic, and paracrine functions, and accumulating evi...
Ahmed Elmaraezy, Xiang-Yang Zhu, A. Eirin et al.· Metabolism and Target Organ...· 0 citations
Aim: Obesity may induce renal microvascular injury, particularly in peritubular capillaries (PTCs). Early detection of these changes may help patient management. We tested the hypothesis that levels of PTC-derived urinary extracellular vesicles (uEVs) reflecting early renal microvascular alterations would be elevated i...
Mina Al-Saeedi, Lei Zhang, Aleksandar Denic et al.· Metabolism and Target Organ...· 0 citations
CKM syndrome entails pathophysiological interactions among the heart, the kidneys, and metabolic derangements. The specific cell populations implicated in renal injury have yet to be identified. We leveraged a new model of CKM syndrome in aging swine and single-nucleus RNA sequencing (snRNA-seq) to investigate the rena...
A. Eirin, S. Sivasankaran, Rhys Sitz et al.· AJP - Renal Physiology· 0 citations
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