Lupus nephritis (LN) is initiated by immune-complex deposition, complement activation, and inflammation, but these mechanisms do not fully explain why some glomerular lesions resolve whereas others progress to podocyte depletion, glomerulosclerosis, and fibrosis. We present a conceptual spatial framework in which grade...
R. S. Hamad, Elsayed A. Elmorsy, A. El-kott et al.· Tissue & Cell· 0 citations
Lysosomal membrane failure contributes to cellular injury by disrupting degradation, metabolism, immune signaling, and compartmental integrity, yet the physical principles that determine whether a mechanically loaded lysosome adapts or ruptures remain incompletely resolved. This review integrates biophysical and molecu...
R. S. Hamad, A. El-kott, Sally Negm et al.· Progress in Biophysics and M...· 0 citations
Biliary tract cancers (BTCs), including cholangiocarcinoma and gallbladder carcinoma, are highly aggressive malignancies associated with poor prognosis, late diagnosis, and limited therapeutic options. Conventional chemotherapy offers only modest survival benefits because of inadequate tumor selectivity, rapid systemic...
Mahvish Fatima, W. Parveen, Norah M. Almaneai et al.· Frontiers in Chemistry· 0 citations
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