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Author

A. El Taher

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Open access Aug 2026

Serum HBsAg cannot distinguish cccDNA activity from integrated HBV DNA expression in chronic hepatitis B virus infection.

BACKGROUND & AIMS HBsAg is currently used as the key serum biomarker to define functional cure of chronic hepatitis B (CHB). Declining HBsAg is often interpreted as evidence of cccDNA elimination or durable transcriptional silencing. However, HBsAg can also be produced from transcriptionally active HBV DNA integrated i...

A. Suslov, M. Matter, D. Calabrese et al. · 0 citations

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