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Open access Sep 2026

Early termination of clinical trials enrolling patients with breast cancer: Reasons, determinants, and temporal patterns

Background The occurrence of clinical trial termination before planned completion (or “early termination” [ET]) remains poorly characterized in the breast cancer field. This study investigates the reasons, determinants, and temporal patterns of ET in breast cancer trials. Methods We conducted a cross-sectional study us...

G. M. Iannantuono, G. Daniele, Luca Mastrantoni et al. · 0 citations
Open access Sep 2026

Prognostic value of hormone receptor expression in patients with HR+/HER2− advanced BC treated with first-line ET+CDK4/6i: results from the multicentre observational, real-world PALMARES-2 study

Effectiveness of first-line ET plus CDK4/6i in patients with HR+/HER2− aBC worsens progressively with decreasing ERα expression, and PgR expression adds further prognostic discrimination, with low ERα and PgR expression identifying a subgroup of patients with particularly poor outcomes.

F. Ligorio, L. Provenzano, R. Caputo et al. · 0 citations

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