Sep 2026
Neuromedin U ‘innervation’ reprograms myeloid immunosuppression in neuroendocrine prostate cancer
Michela Perego, Jozef Madzo, A. Kossenkov et al.
· Oncogene · 0 citations
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A mechanistic framework is established linking AR signaling, JAK2/STAT1 activation, cathepsin B-dependent IL-1[beta] processing, and paracrine cytokine signaling in metastatic CRPC while identifying IL-1[beta] signaling as a potential therapeutic target in advanced prostate cancer.
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