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Sponsored Artificial Intelligence: A Modern Approach, Global Edition Artificial Intelligence: A Modern Approach, Global Edition

Author

A. Fehr

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2 papers indexed here

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Open access Sep 2026

Mutations in the macrodomain 1 of nsp3 attenuate PEDV virulence in vivo without impairing in vitro replication

ABSTRACT The conserved macrodomain 1 (Mac1) within coronavirus nsp3 reverses ADP-ribosylation of proteins and contributes to viral virulence. While Mac1 has been characterized in several coronaviruses, its role in porcine epidemic diarrhea virus (PEDV) remains unknown. Since D445 and N462 are functionally important res...

Ming-De Liu, Men Thi Hoai Duong, Thamonpan Laocharoensuk et al. · 0 citations
Review Open access Sep 2026

SARS-CoV-2 Drug-Resistant Mutations in Non-Structural Proteins

Evaluating the drug resistance mechanisms of multiple SARS-CoV-2 non-structural proteins, including the main protease and the RNA-dependent RNA polymerase, as well as PLPro, EndoU, and Mac1, which contribute to viral replication and counter host innate immune responses are discussed.

Madison Shaw, A. Fehr · 0 citations

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