Author

A. Fiore-Gartland

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Open access Sep 2026

HIV-1 prime-boost vaccination shapes distinct clonal trajectories and memory precursor states of Env- and Gag-specific T cells

Despite decades of HIV-1 vaccine development, the clonal and cellular determinants of durable vaccine-induced T cell memory remain incompletely understood. Here, we combined antigen- specific T cell receptor (TCR) identification, longitudinal TCR sequencing, and single-cell multi- omics to characterize Env- and Gag-spe...

Guo-Yue Xu, Joshua X. Yee, Saskia Ilcisin et al. · bioRxiv · 0 citations

Open access Sep 2026

Uneven TCR chain pairing constraints govern epitope recognition.

Combinatorial pairing of independently recombined T cell receptor (TCR) α- and β-chains is central to diversifying the TCR repertoire. Although sequence motifs in one chain correlate with epitope recognition, the extent to which a single chain dictates specificity remains unclear. Here, we systematically tested TCR cha...

Anastasia A. Minervina, M. Pogorelyy, K. Mayer-Blackwell et al. · Science · 0 citations