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A. Fortuna

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Open access Sep 2026

Tryptophan-enriched diet improves social behavior in a mouse model of tuberous sclerosis complex.

Background: Tryptophan is an essential dietary amino acid and the sole precursor of serotonin (5-HT), a neurotransmitter that plays a key role in cognition, mood regulation, and sensory processing. Because central serotonin synthesis depends on dietary tryptophan availability, nutritional modulation of tryptophan intak...

Mariana Lapo Pais, Carla Fonseca, João Martins et al. · 0 citations
Open access Aug 2026

Intranasal Administration of Isoeugenol Improves Memory Deficits in APP/PS1 Old Mice—A Role Beyond Nrf2 Activation?

Investigating the potential of the skin allergen Isoeugenol to activate Nrf2 and reverse selected AD hallmarks, both in vitro and in vivo, in AD‐specific models reinforces Isoeugenol as a pleiotropic molecule, with great potential for AD treatment.

Ana Silva, Sónia Silva, Jéssica Macedo et al. · 0 citations

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