Neuromuscular Dysfunction and Charcot-Marie-Tooth Disease Reversal in Mfn2 T105M Knock-In Rats
Unprecedented utility of the Mfn2 T105M rat as a model of CMT2A is demonstrated, the menu of clinically applicable tests that may have use in future human trials are expanded, and a strong foundation for exploration of extra-neuronal consequences of pathogenic mitofusin variants in non-mouse models is established.