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A. Franco

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Open access Aug 2026

Neuromuscular Dysfunction and Charcot-Marie-Tooth Disease Reversal in Mfn2 T105M Knock-In Rats

Unprecedented utility of the Mfn2 T105M rat as a model of CMT2A is demonstrated, the menu of clinically applicable tests that may have use in future human trials are expanded, and a strong foundation for exploration of extra-neuronal consequences of pathogenic mitofusin variants in non-mouse models is established.

J. Weigele, A. Franco, Gerald W. Dorn · 0 citations

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