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A. Freischmidt

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Review Open access Oct 2026

Update on somatic mutations in major neurodegenerative diseases: mutational signatures in neurons and mosaicism.

Somatic mutations in major neurodegenerative diseases are poorly understood, but research over the past 2 years provides valuable insights. Single-cell whole-genome sequencing of vulnerable neurons in Alzheimer's disease and amyotrophic lateral sclerosis/frontotemporal dementia (ALS/FTD) revealed excess accumulation of...

A. Freischmidt, Jochen H. Weishaupt · 0 citations

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